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Austin probably has the most nightlife after Vegas from those choices, though I'd probably prefer Orlando (reggae scene).
Cincinnati probably has the best-looking downtown as far as architecture, followed by KC & Cleveland. Sacramento has a nice downtown area also, with the river and Raley Field.
Largest downtown is tough to say, as most of those places are known for their sprawl. San Jose probably is the largest physically of those metros, because you mightas well include Fremont and the Peninsula as they are a part of Greater Silicon Valley.
This is based partially on perception because I havent been to some of them, but:
Las Vegas
Austin
San Antonio
Cleveland
Charlotte/Indianapolis/Kansas City
Cincinnati
San Jose
Columbus
Sacramento
Orlando
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