Best way to get from W and 16thish to Pentagon (transfer to, buy)
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One possibility: ride an S-route metrobus down 16th street to Constitution Ave.
On Constitution Ave., transfer to a 13C- metrobus to the Pentagon.
See http://www.wmata.com/bus/timetables/dc (broken link)
Never underestimate the chaos that often is DC traffic. If I had your commute, I'd walk to U Street metro and take the green and yellow lines there. I can't imagine it taking 48 minutes unless there are constant delays on metro (which, to be sure, are never out of the question). Going the bus route also looks viable.
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