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Old 08-22-2012, 06:20 PM
 
Location: Texas
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Enzymes involved in breaking down fat can now be manipulated to work three times harder by turning on a molecular switch recently observed by chemists at the University of Copenhagen. Being able to control this chemical on/off button could have massive implications for curing diseases related to obesity including diabetes, cardio vascular disease, stroke and even skin problems like acne. But the implications may be wider.
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Old 08-23-2012, 09:13 AM
 
Location: Londonderry, NH
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link?
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Old 08-23-2012, 09:51 AM
 
13,134 posts, read 40,621,897 times
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As an lifelong athlete i've studied Cellular Respiration over the years and know this process well and so i have some issues with the study authors after reading the posted article. I noticed that they didn't name the specific ''enzymes'' that were involved in their research as there are 100's of different types of lipase enzymes involved in the breakdown of fatty acids into energy (ATP) via 3 cycles which are Beta Oxidation, Citric Acid Cycle and the Electron Transport Chain.

All humans individually have a set basal metabolic rate that produces the needed amount of ATP that fuels the entire body and so trying to manipulate that process to further add ATP hence the burning of more fat could backfire as where would the body transport all that extra ATP (electrons) that's not needed? It likely would cause over heating of the cell(s) hence possible cell death hence human death as the body prefers a tight range of 98.6 F.

So forget the so called ''fat burners'' and just crank up the exercise as that'll crank out the breaking down of stored fat for ATP via Beta Oxidation .
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Old 08-23-2012, 11:54 AM
 
Location: Pueblo - Colorado's Second City
12,262 posts, read 24,461,491 times
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I have read that by the middle of the next decade we will be able to eat what we want and gain no weight. This is just one more step to that goal.
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Old 08-24-2012, 10:08 AM
 
5,462 posts, read 9,636,292 times
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Quote:
Originally Posted by GregW View Post
link?
The text in the op is hotlinked to the article. Just click the text.
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Old 08-24-2012, 10:56 AM
 
Location: Victoria TX
42,554 posts, read 86,977,099 times
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Quote:
Originally Posted by Josseppie View Post
I have read that by the middle of the next decade we will be able to eat what we want and gain no weight. This is just one more step to that goal.
Bulimics already do that, using simple physiological principles known to the cavemen.
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Old 08-24-2012, 06:00 PM
 
Location: Pueblo - Colorado's Second City
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Originally Posted by jtur88 View Post
Bulimics already do that, using simple physiological principles known to the cavemen.
I have no desire to be a bulimic as it is unhealthy.
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Old 08-24-2012, 07:14 PM
 
Location: Texas
5,068 posts, read 10,132,051 times
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Quote:
Originally Posted by 6 Foot 3 View Post
As an lifelong athlete i've studied Cellular Respiration over the years and know this process well and so i have some issues with the study authors after reading the posted article. I noticed that they didn't name the specific ''enzymes'' that were involved in their research as there are 100's of different types of lipase enzymes involved in the breakdown of fatty acids into energy (ATP) via 3 cycles which are Beta Oxidation, Citric Acid Cycle and the Electron Transport Chain.

All humans individually have a set basal metabolic rate that produces the needed amount of ATP that fuels the entire body and so trying to manipulate that process to further add ATP hence the burning of more fat could backfire as where would the body transport all that extra ATP (electrons) that's not needed? It likely would cause over heating of the cell(s) hence possible cell death hence human death as the body prefers a tight range of 98.6 F.

So forget the so called ''fat burners'' and just crank up the exercise as that'll crank out the breaking down of stored fat for ATP via Beta Oxidation .
Suppose they just put it at a bit above 98.6 F to 99.6F for a specified amount of time? I do understand that too much is bad for a person. But then there are people who just cannot exercise like a regular person.
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Old 08-25-2012, 06:39 AM
 
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Originally Posted by Brian.Pearson View Post
Suppose they just put it at a bit above 98.6 F to 99.6F for a specified amount of time? I do understand that too much is bad for a person. But then there are people who just cannot exercise like a regular person.
That's a great question although i'll have to defer that to someone more qualified than myself e.g. a physician, as i'd thinkl that even raising the bodies temp by one degree long term ''could'' cause damage somewhere. BTW the body does during certain situations artificially produce added heat as that usually occurs when ill from certain bacteria/viruses in the form of a fever and also when the body temp begins to drop dangerously low for example when exposed to cold weather (hypothermia).

As for exercising to lose fat well one does not need to do that to lose weight as diet alone can accomplish that however it's an added bonus in speeding up the breakdown of fat (lipolysis).

Sidenote: i'm not sure why however the cells really seem to prefer to burn short chain and medium chain fatty acids over what most of us consume daily (meat, plants) which are long chain fatty acids. Might be part of the reason people seem to have more energy when consuming long term coconut oil (medium chain) and even butter (short chain) .
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Old 08-25-2012, 11:34 AM
 
Location: Texas
5,068 posts, read 10,132,051 times
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It could also be that the temperature could be held down to a more normal and just wait for the enzymes to do its stuff. As it stands, my wife likes it cooler and I have to have something to cover me so I can feel "normal" and so she can be "normal". Lots of normals out there...
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