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Old 01-01-2021, 05:36 PM
 
8,274 posts, read 3,475,204 times
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The Oxford/AstraZeneca vaccine is a DNA vaccine. The Moderna and Pfizer vaccines are mRNA vaccines.

Both types of vaccines cause your cells to make the sars-cov-2 spike protein, which will cause the immune system to make antibodies that will fight the virus. However, the mRNA will not, supposedly, stay in your cells indefinitely, since RNA is unstable.

The DNA vaccine is cheaper to make and easier to store and transport, since DNA is stable and doesn't require ultra cold temperatures. But the fact that DNA is stable means that it might stay in your cells indefinitely and continue making the spike protein.

That sounds like a recipe for health complications down the road. But they might show up years later.

 
Old 01-01-2021, 05:48 PM
 
Location: Floribama
18,951 posts, read 43,878,339 times
Reputation: 18771
I'm starting to think my area may reach natural herd immunity before the vaccines ever get here. My BIL, SIL, FIL, nephew, and three friends are currently positive, among many many others. It is spreading fast. I just read that my old middle school coach died from it.
 
Old 01-01-2021, 07:55 PM
 
Location: Georgia, USA
37,368 posts, read 41,636,589 times
Reputation: 45594
Quote:
Originally Posted by Good4Nothin View Post
The Oxford/AstraZeneca vaccine is a DNA vaccine. The Moderna and Pfizer vaccines are mRNA vaccines.

Both types of vaccines cause your cells to make the sars-cov-2 spike protein, which will cause the immune system to make antibodies that will fight the virus. However, the mRNA will not, supposedly, stay in your cells indefinitely, since RNA is unstable.

The DNA vaccine is cheaper to make and easier to store and transport, since DNA is stable and doesn't require ultra cold temperatures. But the fact that DNA is stable means that it might stay in your cells indefinitely and continue making the spike protein.

That sounds like a recipe for health complications down the road. But they might show up years later.
This is how it works:

https://www.nytimes.com/interactive/...stranded%20DNA.

The immune system recognizes the coronavirus spikes produced by the cell infected by the vaccine adenovirus containing the coronavirus spike genes. Antibodies are produced and the cell with the spikes is killed. The adenovirus cannot reproduce and infect more cells. It is once and done.
 
Old 01-01-2021, 08:00 PM
 
8,274 posts, read 3,475,204 times
Reputation: 6127
Quote:
Originally Posted by suzy_q2010 View Post
This is how it works:

https://www.nytimes.com/interactive/...stranded%20DNA.

The immune system recognizes the coronavirus spikes produced by the cell infected by the vaccine adenovirus containing the coronavirus spike genes. Antibodies are produced and the cell with the spikes is killed. The adenovirus cannot reproduce and infect more cells. It is once and done.
Well hopefully it will always work that way. If it does, it might be safer than the mRNA vaccines.
 
Old 01-01-2021, 08:08 PM
 
Location: Georgia, USA
37,368 posts, read 41,636,589 times
Reputation: 45594
Quote:
Originally Posted by Good4Nothin View Post
Well hopefully it will always work that way. If it does, it might be safer than the mRNA vaccines.
The mRNA is once and done, too.

The difference between the platforms is the number of steps involved. The result - human cells displaying spike proteins - is the same.
 
Old 01-01-2021, 08:37 PM
 
Location: near bears but at least no snakes
26,667 posts, read 28,908,995 times
Reputation: 50595
A lot of posts have been deleted for being off topic or fighting or a reply to one of those posts. This thread is now closed.
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