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This is probably not worth very much, but it has been my very casual and unscientific observation in reading dozens of these kinds of threads that if people are very close to their extended family, they almost invariably regret moving away from them. However, for people without that kind of closeness and who do what want they think would be better for them -- and if they have done as much research as possible (including actually spending time in their top "location possibilities" in every season before they list their existing home -- most of the time, most of those people are happy with their decision to move.
We moved from the West Coast to North Carolina. The culture, the people, . . . those were fine. But the climate!! I couldn't take the heat, and we are back on the West Coast.