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Some of them have silicone padding to prevent damage--if you can find one of them, you're good to go. Otherwise I'd be careful if the desk is a nice piece of hardwood furniture.
I had a corked (or padded or something) years and years ago... on a laminate desk like the one in your picture. Never damaged the surface really, but the thing kept coming loose and had to retighten all the time. Finally, one day the lamp got bumped after it was really tight and broke the whole desk top.
So to answer your question - no, it won't damage your desk, just the clutzy people around it will! LOL
If it is cushioned properly, it should not harm the desk.
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