We had one rescue get out about 20 years ago and hit by a car. When we moved to a rural area, we had a neutered Maine Coon cat who liked to get outside. He was a big guy, about 18 pounds and he was sassy enough to chase the neighbor's dog out of the yard. Then he disappeared for three months before finally showing up skinny enough to have his ribs showing and with all the fur on his neck rubbed off. I guess some local mental case got hold of him and had him tied up someplace.
Had the vet check him for broken bones. Thankfully none were found. But he either ate a poisoned rodent or had been poisoned deliberately.
After a few days at the vet's to be sure we took him home and a couple of weeks of good eating he was back to his sassy old self again. He lived for several years after that. We tried keeping him inside, but he did manage to get out and unfortunately got hit by a truck not far from home.
Our most recent rescue is a tabby who is a dedicated house cat who fortunately shows no interest in going outside.