The Tri-State area has seven hospitals that serve the community, with a total of 1,300 beds. The largest in the area, and second largest in the state, is St. Mary's Hospital. With 400 beds and centers in cardiac care, neuroscience, diabetes, and cancer treatment, St. Mary's is a teaching hospital for Marshall Univerity's School of Medicine and School of Nursing. Cabell Huntington Hospital, a 291-bed facility, opened the 50,000 square-foot Edwards Comprehensive Cancer Center in 2005. The hospital is also home to West Virginia's only Burn Intensive Care Unit, a Neonatal Intensive Care Unit, and a Joint Replacement unit that opened in 2004. The Huntington VA Medical Center serves veterans with a 50-bed acute care and surgical hospital and 4 outpatient clinics.
Valley Health operates 22 general health care centers and public health programs. Health South operates two centers in the area: the Rehabilitation Hospital of Huntington and the Cabell-Huntington Outpatient Surgery Center. The Prestera Center provides outpatient mental health services for adults, children, and families, and has inpatient substance abuse and psychiatric facilities. Mildred Mitchell-Bateman Hospital is an adult inpatient psychiatric facility, and River Park Hospital provides inpatient services for both adults and adolescents. Genesis HealthCare runs Heritage Center, an 189-bed eldercare and rehabilitation center.