Natrona County International Airport (NCIA) is Wyoming's largest airport and is located at the geographic center of the state. Four regional carriers provide service through NCIA, including Delta, Sky West, United, and Northwest Airlines.
Casper's central location makes it a highway hub, with Interstate 25, U.S. Highways 20 and 87, and state highways 220, 254, and 20 all meeting within its city limits. Casper is served by the Greyhound bus company, which maintains a station in the Parkway Plaza Hotel.
While Casper is fitted to the meandering contours of the North Platte River, the streets are laid out on a straightforward north-south, east-west grid pattern. Numbered streets run east and west, while name streets run north and south for the most part, making navigation simpler.
In April of 2005, Casper inaugurated its new fixed route transit system, known as " The Bus." With 4 routes and 65 stops, The Bus will offer reduced fares to elderly and disabled patrons.
The 11-mile Platte River Parkway provides a safe and fast route for bike commuters to ride into downtown Casper.