Pennsylvania participates in such regional bodies as the Atlantic States Marine Fisheries Commission, Susquehanna River Basin Commission, Ohio River Valley Water Sanitation Commission, Wheeling Creek Watershed Protection and Flood Prevention Commission, and Great Lakes Commission. In 1985, Pennsylvania, seven other Great Lakes states, and the Canadian provinces of Quebec and Ontario signed the Great Lakes Compact to protect the lakes' water reserves. Other agreements include the Mid-Atlantic Fishery Management Council, Interstate Mining Compact Commission, Ohio River Basin Coimmission, Appalachian Regional Commission, Brandywine River Valley Compact, New Jersey-Pennsylvania Turnpike Bridge Compact, Potomac Valley Conservancy District, Pymatuning Lake Compact, and the Tri-State Agreement on the Chesapeake Bay.
Some of the most important interstate agreements concern commerce and development along the Delaware River. The Delaware River Basin Commission involves the governors of Delaware, New Jersey, New York, and Pennsylvania in the utilization and conservation of the Delaware and its surrounding areas. Through the Delaware River Port Authority, New Jersey and Pennsylvania control an interstate mass transit system. The two states also are signatories to the Delaware River Joint Toll Bridge Compact and Delaware Valley Regional Planning Commission. During 2001, Pennsylvania received over $14.8 billion in federal grants (4th among the 50 states).