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Trish Webster died of acute gastrointestinal illness after several months of taking Ozempic and Saxenda.
She saw an ad for Ozempic on TV and reached out to her doctor for a prescription in 2022. But while she was struggling with gastrointestinal side effects like diarrhea, she kept using Ozempic.
As in the United States, Ozempic is approved in Australia for people with type 2 diabetes — not weight-loss
Ozempic is one of the brand names for semaglutide and tirzepatide — also marketed under the brand name Wegovy, which, unlike Ozempic, is approved for weight-loss management. They work by acting on the brain to impact feelings of satiety, or fullness.
After a few months, Trish switched to Saxenda — another injectable — to lose even more weight. Like semaglutide and tirzepatide, the active ingredient in Saxenda — liraglutide — regulates the appetite.
And then, on January 16 of this year, Trish Webster stopped breathing....
But WITHOUT the appetite suppressing and motility slowing effects of the drug, which is the only thing enabling them to eat less (often for the first time in years or decades), the majority of people most likely will once again eat more without the drug. It doesn't "teach you new habits" or "instill willpower"; it simply makes you less hungry -- a temporary effect, it turns out.
If you combine the drug with "paying attention" skills, like noticing what you're eating now that your appetite is reduced, and noticing the weight you're losing while being forced to stick with a reduced calorie diet...
then you CAN successfully stop taking the drug, and NOT gain the weight back.
When someone says "you WILL" gain the weight back when you get off the drug, they are either lying, exaggerating, or displaying a remarkable sense of ignorance.
It isn't guaranteed that you WILL gain the weight back. The fact is, you CAN gain the weight back. You can also NOT gain the weight back. It depends on how well you hone your "paying attention" skills while using the medication.
True. OR they could just "pay attention" to what they're eating and eat less WITHOUT the drug and have the same result. But people apparently CAN'T, or else they would.
True. OR they could just "pay attention" to what they're eating and eat less WITHOUT the drug and have the same result. But people apparently CAN'T, or else they would.
Unless they have a particular illness which makes it impossible for them to feel full, they CAN pay attention to what they're eating. They choose not to, or they've fallen into the habit of not doing so, and have not succeeded (yet) in getting rid of their bad habits. That doesn't mean they're not capable of changing. It just means they haven't reached the point in their lives where they can. Yet. Depression can lead to binge eating, and other poor dietary habits. But with help - sometimes psychological, sometimes medical, sometimes both - they can change their habits.
Okay; they "choose not to"; whatever. My only point is that if they could or would do it without the drug, they would have, but they didn't. So there's no reason to believe that they'll suddenly learn how to or be inspired to eat less once they're off the drug and their normal appetite and digestion returns. The weight will return, or they'll stay on the drug for life to avoid it.
Okay; they "choose not to"; whatever. My only point is that if they could or would do it without the drug, they would have, but they didn't. So there's no reason to believe that they'll suddenly learn how to or be inspired to eat less once they're off the drug and their normal appetite and digestion returns. The weight will return, or they'll stay on the drug for life to avoid it.
It's intended to be a (singular) tool in the toolbox of the obese, in the journey of return to health. If you're obese, it'll take months to lose enough weight to be considered no longer at risk. During those months, it's assumed you are ALSO learning portion control, hopefully getting mental health counselling to combat whatever caused you to become obese in the first place, creating a sustainable fitness routine, and so on.
Once you stop taking the drug, by then your stomach would have shrunken somewhat - so you won't have "hungry" as an excuse to overeat. At that point, you will have already developed a fitness routine, learned HOW to eat, and have a support team in the form of a therapist, group, or both.
There is nothing easy about losing weight when you're obese. And you WOULD learn this, during the months that you are taking that drug so that by the time you're ready to stop taking it, you'll already be prepared to keep the weight off.
Many people fail. But some succeed and continue to live healthy, fit, non-obese lives.
Lack of will power and lack of self discipline are character flaws, but you are making a wild assumption that every obese person desperately wants to be thin.
Healthy weight range should be the goal.
I would have a BMI of just over 30, so it definitely needs attention.
Co-morbidities like arthritis, working shift work (sleep issues), all contribute to the problem.
That and a genetic predisposition.
The holiday period doesn’t help either, as most of us do overindulge in food and alcoholic drinks.
These drugs and medications may help, but are certainly not for everyone.
There’s also a risk with any drug or medication, but most have to pass rigorous testing to get registered in the first place. (although this is cold comfort to this case)
Co-morbidities like arthritis, working shift work (sleep issues), all contribute to the problem.
That and a genetic predisposition...
That, and (as someone explained in depth on this or another thread; I forget) menopause, HRT, age, being female, and repeated dieting/fasting all contribute to the body's tendency to hold onto weight or put it back on, returning one to a set point. I've known too many people who eat "badly" and stay thin or eat well but gain easily or can't lose to doubt it. Speaking personally as someone who was first very thin no matter what or how much I ate, then as someone who could put on weight but also take it off with just a week of eating less and moving more, and now as someone who can't budge from a number 10-15 pounds over what I'd like to be no matter what I do, it's not as simple for all of us as "calories in, calories out." Maybe it is for men and young people (I didn't used to believe "the excuses," either), but some people don't know what they don't know!
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