Jefferson City is located at the crossroads of U.S. Highways 54 and 63, which run north and south, and U.S. Highway 50, which runs east and west. Columbia Regional Airport, about twelve miles north of downtown, has commuter air carrier service. The airport shuttle offers trips downtown, and taxi service is also available. Amtrak offers train transportation to the city and bus service is provided by Sho-Me Coach Lines.
Highway 50/63 runs east and west through the city just two blocks south of the State Capitol Building; in town it is known as the Whitton Expressway. Highway 54, known as Christy Lane, runs north to Fulton and south to the Lake of the Ozarks State Park. Downtown, West Main Street and East Capitol Avenue run directly to the Missouri Capitol Building. Jefferson City is served by Jefferson City Transit's JEFFTRAN bus line.