Airport shuttles make round trips from Portland International Airport, 61 miles from Salem. Interstate 5, the major West Coast interstate highway, and Interstate 84, for destinations to the east, run through Salem. Passenger rail service is available from Amtrak with two trains daily. The city is also served by Greyhound bus line.
The downtown area and much of the rest of Salem is laid out in a grid pattern. Major thoroughfares include State Street, Center Street, Commercial Street, and River Road. Salem-Keizer Transit, also known as Cherriots, operates 25 bus lines with a fleet of more than 50 buses throughout the metropolitan area.